Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

11.3K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
11.3K
RNA-seq03:21

RNA-seq

10.1K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrical discrimination of lysine methylation states at the single-molecule level.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2026
Same author

Single-molecule detection of amino acid phosphorylation using electron tunnelling currents: toward neurodegenerative disease diagnosis.

Nanoscale·2026
Same author

Beyond ensemble averages: single-entity approaches for complex systems.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry·2026
Same author

Rapid diagnosis of ocular viral infections via single-virus detection using solid-state nanopore: A diagnostic evaluation study.

PNAS nexus·2025
Same author

Anion vacancies activate N<sub>2</sub> to ammonia on Ba-Si orthosilicate oxynitride-hydride.

Nature chemistry·2025
Same author

Altered genomic methylation promotes Staphylococcus aureus persistence in hospital environment.

Nature communications·2024

Related Experiment Video

Updated: Jul 23, 2025

Production and Targeting of Monovalent Quantum Dots
10:16

Production and Targeting of Monovalent Quantum Dots

Published on: October 23, 2014

25.6K

Single-Molecule Identification of Nucleotides Using a Quantum Computer.

Masateru Taniguchi1, Takahito Ohshiro1, Tomofumi Tada2

  • 1SNAKEN, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047 Japan.

The Journal of Physical Chemistry. B
|July 19, 2023
PubMed
Summary
This summary is machine-generated.

Quantum computing can now identify single DNA nucleotides, a key step for personalized medicine. This breakthrough enables faster genome analysis using quantum computers for health innovations.

More Related Videos

Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA
12:35

Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA

Published on: November 14, 2017

9.5K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.0K

Related Experiment Videos

Last Updated: Jul 23, 2025

Production and Targeting of Monovalent Quantum Dots
10:16

Production and Targeting of Monovalent Quantum Dots

Published on: October 23, 2014

25.6K
Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA
12:35

Simultaneous Mapping and Quantitation of Ribonucleotides in Human Mitochondrial DNA

Published on: November 14, 2017

9.5K
Author Spotlight: Advancements in DNA Nanosensors &#8211; Addressing Sensitivity and Selectivity Challenges in Molecular Detection
07:16

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

1.0K

Area of Science:

  • Quantum computing
  • Genomics
  • Biotechnology

Background:

  • Genomic information is crucial for human health.
  • Quantum computing offers potential for analyzing large genomic datasets.
  • Current quantum computing applications have not included genomic analysis, such as nucleotide identification.

Purpose of the Study:

  • To demonstrate single-molecule nucleotide identification using a quantum computer.
  • To design a quantum gate capable of distinguishing between the four DNA nucleotides.
  • To lay the foundation for quantum-enhanced genome analysis.

Main Methods:

  • Designed a quantum gate to model the electronic conductance of adenosine.
  • Developed a quantum circuit incorporating a reverse and an encoding gate.
  • Utilized quantum computation for single-molecule conductance analysis.

Main Results:

  • Successfully demonstrated single-molecule identification of nucleotides using a quantum computer.
  • The designed quantum gate effectively distinguishes adenosine from other nucleotides.
  • Established a quantum circuit capable of nucleotide differentiation.

Conclusions:

  • This study presents the first instance of single-molecule nucleotide identification via quantum computing.
  • The developed quantum gate and circuit are crucial for advancing quantum genome analysis.
  • These findings represent a significant stride towards realizing quantum-accelerated personalized medicine and drug discovery.