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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
Published on: February 12, 2016
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Macrophage and monocyte subsets in response to ischemic stroke
Nelli Blank-Stein1, Elvira Mass1
1Developmental Biology of the Immune System, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
European Journal of Immunology
|July 19, 2023
Summary
This review explores macrophage roles in neuroinflammation after ischemic stroke, identifying potential therapeutic targets beyond acute recanalization. Understanding these immune cells offers new avenues for stroke treatment.
Area of Science:
- Neuroscience
- Immunology
- Pathology
Background:
- Ischemic stroke is a major cause of death and disability worldwide.
- Current pharmacological treatment, arterial recanalization, is limited to the acute phase.
- The neuroinflammatory response presents a broader therapeutic window.
Purpose of the Study:
- To review recent advances in understanding macrophage populations after stroke.
- To identify potential therapeutic targets within the neuroinflammatory response.
- To highlight the impact of aging on immune responses in stroke.
Main Methods:
- Review of current literature on macrophage biology in stroke.
- Analysis of cellular and molecular responses of distinct macrophage populations.
- Discussion of local and infiltrating immune cells.
Main Results:
- Microglia, border-associated macrophages, and skull bone marrow-derived macrophages are key local responders.
- Monocytes from bone marrow and spleen infiltrate the brain.
- Aging significantly modulates the immune response to stroke.
Conclusions:
- Distinct macrophage populations play critical roles in post-stroke neuroinflammation.
- Targeting these macrophage populations offers promising therapeutic strategies.
- Further research should consider the influence of aging on stroke outcomes.
