Related Experiment Video

Updated: Jul 23, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

19.7K

Left ventricular global longitudinal strain as a prognosticator in hypertrophic cardiomyopathy with a low-normal left

You-Jung Choi1,2, Hyun-Jung Lee2,3, Ji-Suck Park4

  • 1Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.

European Heart Journal. Cardiovascular Imaging
|July 19, 2023
PubMed

Insights

Left ventricular global longitudinal strain (LV-GLS) is a key predictor of cardiovascular events in hypertrophic cardiomyopathy (HCM) patients with preserved ejection fraction. Lower LV-GLS values (≤10.5%) indicate a higher risk, aiding in patient risk stratification.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Biomarkers

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease.
  • Left ventricular ejection fraction (LVEF) of 50-60% is considered preserved but may mask underlying myocardial dysfunction.
  • Prognostic markers are crucial for risk stratification in HCM patients with preserved LVEF.

Purpose of the Study:

  • To evaluate the prognostic significance of left ventricular global longitudinal strain (LV-GLS) in patients with HCM and LVEF between 50-60%.
  • To determine if LV-GLS can predict adverse cardiovascular outcomes in this specific HCM subgroup.

Main Methods:

  • Retrospective cohort study of 349 HCM patients with LVEF 50-60%.
  • Primary outcome: composite of cardiovascular death, including sudden cardiac death (SCD) and SCD-equivalent events.
  • Secondary outcomes: SCD/SCD-equivalent events, cardiovascular death, and all-cause death.
  • Statistical analysis included adjusted hazard ratios and receiver operating characteristic analysis to identify optimal cut-off values.

Main Results:

  • Absolute LV-GLS was independently associated with the primary composite outcome (adjusted HR 0.88, P=0.029).
  • An optimal cut-off of 10.5% for absolute LV-GLS was identified.
  • Patients with absolute LV-GLS ≤ 10.5% had a significantly higher risk of the primary outcome (adjusted HR 2.54, P=0.026).
  • Absolute LV-GLS ≤ 10.5% also independently predicted secondary outcomes.

Conclusions:

  • LV-GLS is an independent predictor of cardiovascular death and SCD/SCD-equivalent events in HCM patients with preserved LVEF (50-60%).
  • LV-GLS measurement can enhance risk stratification in this patient population.
  • The findings support the use of LV-GLS in clinical decision-making for HCM management.
Abstract

Keywords:
left ventricular systolic dysfunctionmortalityrisk stratificationsudden cardiac death

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.0K
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.4K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
16
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
23
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
18
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
17
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
27