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A Core-Shell Nanoreinforced Ion-Conductive Implantable Hydrogel Bioelectronic Patch with High Sensitivity and

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  • 1Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.

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This study introduces a novel hydrogel patch for simultaneous heart repair and electrophysiological monitoring after myocardial infarction (MI). The bioactive patch promotes healing and tracks cardiac signals in real-time.

Keywords:
cardiac patchesflexible mechanoelectrical sensingmyocardial infarctionnanocomposite reinforcementreal-time cardiac monitoring

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Cardiovascular Engineering

Background:

  • Myocardial infarction (MI) poses significant challenges for synchronous repair and real-time monitoring.
  • Existing treatments often lack integrated solutions for both cardiac repair and continuous electrophysiological assessment.

Purpose of the Study:

  • To develop a novel core-shell-structured curcumin-nanocomposite-reinforced ion-conductive hydrogel patch.
  • To achieve synchronous monitoring of heart electrophysiological signals and infarcted heart repair.
  • To investigate the patch's efficacy in regulating the inflammatory microenvironment, promoting angiogenesis, and reducing myocardial fibrosis.

Main Methods:

  • Synthesis of a core-shell-structured curcumin-nanocomposite-reinforced ion-conductive hydrogel.
  • Characterization of the hydrogel's elasticity, mechanoelectrical sensitivity, and sensing capacity.
  • In vitro and in vivo experiments to evaluate the hydrogel's performance in MI repair and signal monitoring.

Main Results:

  • The nanoreinforced hydrogel exhibited excellent elasticity, ultrahigh mechanoelectrical sensitivity (37 ms), and reliable sensing capacity (>3000 cycles).
  • In vitro and in vivo studies confirmed the hydrogel's ability to regulate the inflammatory microenvironment, promote angiogenesis, and reduce myocardial fibrosis.
  • The hydrogel sensors accurately acquired cardiac signals, enabling real-time monitoring of the entire MI healing process.

Conclusions:

  • The developed bioactive and electrophysiological-sensing ion-conductive hydrogel cardiac patch offers a versatile strategy for integrated MI monitoring and repair.
  • This approach promises synchronous real-time monitoring of MI status and excellent repair performance.
  • The findings highlight a novel pathway for advancing cardiovascular regenerative medicine and diagnostics.