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Updated: Jul 23, 2025
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Animal models of complex regional pain syndrome: A scoping review
Juliete Palandi1, Josiel Mileno Mack2, Isabela Longo de Araújo2
1Laboratory of Experimental in Neuropathology (LEN), Graduate Program in Neuroscience, Biochemistry Department, Biological Sciences Center, Universidade Federal de Santa Catarina (UFSC), 88040-900 Florianópolis, SC, Brazil.
Background:
complex regional pain syndrome (CRPS) leads to a debilitating chronic pain condition. The lack of cause, etiology, and treatment for CRPS has been widely explored in animal models.
Objective:
Provide a comprehensive framework of the animal models used for investigating CRPS.
Eligibility Criteria:
Preclinical studies to induce the characteristics of CRPS, with a control group, in any language or publication date.
Sources Of Evidence:
The search was performed in the Medline (PubMed) and ScienceDirect databases.
Results:
93 studies are included. The main objective of the included studies was to understand the CRPS model. Rats, males and adults, exposed to ischemia/reperfusion of the paw or fracture of the tibia were the most common characteristics. Nociceptive evaluation using von Frey monofilaments was the most widely adopted in the studies.
Conclusions:
For the best translational science between the animal models and individuals with CRPS, future studies should include more heterogeneous animals, and multiple assessment tools, in addition to improving the description and performance of measures that reduce the risk of bias.
