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Related Experiment Video

Updated: Jul 23, 2025

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Default Mode Network Hypoalignment of Function to Structure Correlates With Depression and Rumination.

Paul J Thomas1, Alex Leow1, Heide Klumpp2

  • 1Department of Biomedical Engineering, University of Illinois Chicago, Chicago, Illinois.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|July 19, 2023
PubMed
Summary
This summary is machine-generated.

Brain signal alignment in the default mode network (DMN) is reduced in individuals with internalizing disorders and linked to depression and rumination. This study uses graph signal processing to analyze brain network function in these conditions.

Keywords:
DepressionGraph LaplacianGraph signal processingNeuroimagingRumination

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Area of Science:

  • Neuroscience
  • Graph Signal Processing
  • Psychiatry

Background:

  • Graph signal processing (GSP) tools quantify brain function alignment with white matter structure.
  • This framework is applied to a transdiagnostic cohort with internalizing psychopathologies (mood and anxiety disorders).
  • The study investigates the relationship between default mode network (DMN) alignment and depression/rumination symptoms.

Purpose of the Study:

  • To apply GSP to analyze DMN signal alignment in internalizing psychopathologies.
  • To determine if DMN signal alignment is associated with depression and rumination.
  • To explore the link between DMN functional connectivity and structural network topology.

Main Methods:

  • Diffusion-weighted and resting-state functional MRI data were acquired from 60 patients and 19 healthy controls.
  • Participants received 12 weeks of treatment (SSRI or CBT), with symptom re-evaluation.
  • GSP methodology quantified functional signal alignment to white matter structural networks.

Main Results:

  • Posterior DMN signal alignment was decreased in patients with internalizing psychopathologies compared to controls.
  • Decreased signal alignment negatively correlated with baseline depression and rumination scores.
  • Posterior DMN signal alignment correlated with the ratio of within-DMN to extra-DMN functional connectivity.

Conclusions:

  • Findings support previous literature on posterior DMN connectivity in internalizing disorders.
  • This is the first GSP analysis in a transdiagnostic cohort with internalizing psychopathologies.
  • Altered DMN signal alignment may be a neural marker for depression and rumination.