Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

154
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
154
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

356
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
356
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

296
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
296
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

220
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
220
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

174
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
174
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

171
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
171

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Escalating anti-tumour necrosis factor exposure with reductions in surgical resection rates in paediatric inflammatory bowel disease: an 18-year real-world population-based cohort study.

BMJ open gastroenterology·2026
Same author

Evaluating the need for biopsy in coeliac disease diagnosis.

BMJ (Clinical research ed.)·2026
Same author

Learning from the past, structuring the future: using large language models to unlock a century of paediatric research in <i>Archives of Disease in Childhood</i>.

Archives of disease in childhood·2025
Same author

Risk stratification of IBD-associated liver disease using routinely collected biomarkers from a large-scale real-world dataset.

BMJ open gastroenterology·2025
Same author

<i>Archives of Disease in Childhood</i>: Publishing papers to impact on practice 1926-2026.

Archives of disease in childhood·2025
Same author

British Society of Gastroenterology adult guidelines on inflammatory bowel disease: what can we learn for children and young people?

Gut·2025

Related Experiment Video

Updated: Jul 23, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.2K

Inflammatory bowel disease: recent developments.

James John Ashton1,2, R Mark Beattie3

  • 1Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.

Archives of Disease in Childhood
|July 19, 2023
PubMed
Summary
This summary is machine-generated.

Pediatric inflammatory bowel disease (IBD) is rising in children, with new diagnostic tools and advanced therapies like biologics. Personalized treatment strategies are key for managing this complex condition in young patients.

Keywords:
GastroenterologyPaediatrics

More Related Videos

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

4.0K
Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes
08:52

Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes

Published on: February 5, 2021

4.5K

Related Experiment Videos

Last Updated: Jul 23, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.2K
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

4.0K
Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes
08:52

Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes

Published on: February 5, 2021

4.5K

Area of Science:

  • Pediatric Gastroenterology
  • Immunology
  • Internal Medicine

Background:

  • Pediatric-onset inflammatory bowel disease (IBD) incidence has doubled in 25 years, with increasing prevalence and severity.
  • Diagnostic tools for IBD in children have advanced, including fecal calprotectin, small bowel imaging, and capsule endoscopy.
  • Management options have expanded, incorporating novel targeted therapies and improved drug monitoring.

Purpose of the Study:

  • To summarize recent advancements in the diagnosis, investigation, and management of pediatric IBD.
  • To highlight the evolving landscape of IBD care for children and young people.
  • To discuss the future of personalized and stratified treatment approaches.

Main Methods:

  • Review of recent literature on pediatric IBD diagnosis and management.
  • Analysis of advancements in diagnostic technologies.
  • Evaluation of emerging therapeutic strategies and monitoring techniques.

Main Results:

  • Improved diagnostic accuracy with tools like fecal calprotectin and advanced imaging.
  • Introduction of targeted therapies (e.g., anti-IL-12/23, JAK-STAT inhibitors) and refined monitoring of established treatments.
  • Recognition of IBD as a disease continuum with diverse phenotypes.

Conclusions:

  • Recent developments offer improved diagnostic and management options for pediatric IBD.
  • Personalized and stratified treatment strategies, utilizing biomarkers, are crucial for future care.
  • Multidisciplinary collaboration within clinical networks is essential for optimal outcomes in pediatric IBD.