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Clinical relevance of viral codetection in infants with respiratory syncytial virus bronchiolitis

Albert Bernet Sánchez1, Alba Bellés Bellés1, Mercè García González1

  • 1Sección de Microbiología, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Institut de Recerca Biomèdica de Lleida (IRBLleida), Lleida, Spain.

Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)
|July 19, 2023
PubMed

Insights

Viral codetection with respiratory syncytial virus (RSV) in infants is common but does not increase the severity of RSV bronchiolitis. This finding is crucial for understanding infant respiratory infections.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Respiratory syncytial virus (RSV) is a primary cause of severe bronchiolitis in infants.
  • Assessing the impact of co-detected respiratory viruses alongside RSV is critical for understanding disease severity.

Purpose of the Study:

  • To evaluate if the codetection of RSV with other respiratory viruses influences the severity of bronchiolitis in infants compared to isolated RSV infection.

Main Methods:

  • A prospective study conducted from 2016-2019 involved children under 2 years with RSV bronchiolitis.
  • Real-time PCR and multiplex PCR were used for viral detection in nasopharyngeal samples.
  • Clinical data including hospital stay, BROSJOD score, and ICU admission were analyzed.

Main Results:

  • Of 437 RSV bronchiolitis cases, 199 (45.5%) showed co-detection of another respiratory virus.
  • Bivariant analyses revealed no statistically significant differences in severity markers between unique RSV and viral co-detection groups.

Conclusions:

  • Viral co-detection is a frequent occurrence in infants diagnosed with RSV bronchiolitis.
  • Current evidence suggests that viral co-detection does not appear to exacerbate the severity of RSV bronchiolitis in this population.
Abstract

Keywords:
BronchiolitisBronquiolitisCodetecciónCodetectionCoinfecciónCoinfectionRespiratory syncytial virusRespiratory virusesVirus respiratorio sincitialVirus respiratorios

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