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Estimating long-term vaccine effectiveness against SARS-CoV-2 variants: a model-based approach

Alexandra B Hogan1,2, Patrick Doohan2, Sean L Wu3

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Nature Communications
|July 19, 2023
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Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
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Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
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Model Approaches for Pharmacokinetic Data: Physiological Models

Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
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