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Association between statin use and open-angle glaucoma: a nested case-control study using the Japanese claims
Satoshi Yokoyama1, Chihiro Nakagawa2, Kouichi Hosomi2
1Division of Drug Informatics, School of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashiōsaka City, Osaka, 577-8502, Japan. yokoyama@phar.kindai.ac.jp.
Scientific Reports
|July 19, 2023
Summary
This study found no significant link between statin use and open-angle glaucoma (OAG) in Japanese patients with dyslipidemia. Statin therapy did not increase the risk of developing OAG in this population.
Area of Science:
- Ophthalmology
- Pharmacology
- Epidemiology
Background:
- The relationship between statin use and open-angle glaucoma (OAG) is debated.
- Dyslipidemia is a common condition often treated with statins.
Purpose of the Study:
- To investigate the association between statin use and the risk of developing OAG.
- To analyze this relationship in a Japanese population with dyslipidemia.
Main Methods:
- A nested case-control study was conducted using the JMDC claims database (2005-2020).
- Cases were identified by OAG diagnosis, anti-glaucoma drug prescription, or glaucoma surgery.
- Statin exposure was assessed based on prescription data in the 12 or 24 months prior to the index date.
Main Results:
- The study included 375,373 patients with newly diagnosed dyslipidemia.
- Statin use was not found to be a significant risk factor for OAG (Model 1 aOR: 0.98, 95% CI: 0.93-1.03; Model 2 aOR: 0.97, 95% CI: 0.91-1.04).
- Short-term statin exposure (< 2 years) was not associated with an increased OAG risk.
Conclusions:
- Statin use does not appear to be a significant risk factor for open-angle glaucoma in Japanese patients with dyslipidemia.
- Further research may be warranted to explore potential long-term effects or specific patient subgroups.
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