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Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S

Haipeng Guan1,2, Pei Wang1,2, Pei Zhang1,2

  • 1State Key Laboratory of Molecular Oncology, MOE Key Laboratory of Protein Sciences, SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, School of Medicine, Tsinghua University, Beijing, China.

Nature
|July 19, 2023
PubMed
Summary

The Rpd3S complex uses unique structures to recognize histone marks like H3K36me3, guiding gene regulation. This epigenetic machinery demonstrates complex, dynamic nucleosome engagement for precise deacetylation.

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