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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

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INFRAFRONTIER: mouse model resources for modelling human diseases.

Asrar Ali Khan¹, Gema Valera Vazquez², Montse Gustems²

¹INFRAFRONTIER GmbH, Neuherberg, Germany. asrar.khan@infrafrontier.eu.

Mammalian Genome : Official Journal of the International Mammalian Genome Society

|July 19, 2023

Summary

INFRAFRONTIER offers advanced mouse models and services for human disease research across Europe. This infrastructure enhances access to cutting-edge technologies for the biomedical research community.

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Area of Science:

Biomedical Research
Genetics
Disease Modeling

Background:

INFRAFRONTIER is a leading European Research Infrastructure for mouse models.
It comprises 22 partners across 15 countries.
The network focuses on generation, phenotyping, archiving, and distribution of mouse models.

Purpose of the Study:

To highlight recent INFRAFRONTIER developments and services.
To inform the research community about available resources.
To showcase advancements in human disease modeling technologies.

Main Methods:

Utilizing a comprehensive INFRAFRONTIER database.
Leveraging Curated Disease Models for research.
Providing access to Cancer and Rare Disease resources.
Offering state-of-the-art services.

Main Results:

INFRAFRONTIER has established itself as a world-class infrastructure.
The network continuously expands its portfolio of resources and services.
Accessibility of cutting-edge disease modeling technologies is enhanced.

Conclusions:

INFRAFRONTIER plays a crucial role in advancing biomedical research in Europe.
The infrastructure supports non-profit research by providing valuable tools and expertise.
Continued development ensures broad access to essential research resources.