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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Updated: Jul 23, 2025

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas
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Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP).

Sanjay Jain1,2,3, Liming Pei4, Jeffrey M Spraggins5

  • 1Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. sanjayjain@wustl.edu.

Nature Cell Biology
|July 19, 2023
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Summary

The Human BioMolecular Atlas Program (HuBMAP) is creating a detailed spatial map of the human body at single-cell resolution. This initiative will provide essential tools and data to advance biomedical research and understanding of human tissues.

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Area of Science:

  • Human biology
  • Biomedical research
  • Spatial omics

Background:

  • The Human BioMolecular Atlas Program (HuBMAP) has completed its initial phase, focusing on ontologies, protocols, and pipelines.
  • The program aims to create a comprehensive spatial atlas of the human body.

Purpose of the Study:

  • To introduce the production phase of the HuBMAP initiative.
  • To detail the generation of reference spatial maps of functional tissue units.
  • To develop mapping tools and infrastructure for biomedical research.

Main Methods:

  • Application of advanced technologies for spatial mapping.
  • Generation of single-cell resolution data.
  • Integration of data from diverse organs and populations.

Main Results:

  • The perspective outlines the transition to the production phase of HuBMAP.
  • Focus on creating multi-scale spatial atlases of human tissues.
  • Development of new tools and infrastructure is underway.

Conclusions:

  • The HuBMAP production phase will generate valuable spatial maps and resources.
  • These resources will significantly advance biomedical research.
  • The program emphasizes community dissemination of data and tools.