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Updated: Jul 23, 2025

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TMPOP2 Inhibition Suppresses Pancreatic Cancer Cell Migration and Development by Repressing The JNK/STAT3 Pathway

Jun Liang1, Huangming Cao2, Guangxue Wang3

  • 1Department of Oncology Medicine Center, Shanghai East Hospital, School of Medicine,Tongji University, Shanghai, 200092, China.

Advanced Biology
|July 20, 2023
PubMed

Insights

Long non-coding RNA TMPOP2 promotes pancreatic cancer progression by enhancing cell migration and epithelial-mesenchymal transition (EMT). Inhibiting TMPOP2 may offer a new therapeutic strategy for pancreatic cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pancreatic cancer has a poor prognosis and high mortality.
  • Long non-coding RNA (lncRNA) TMPOP2 is implicated in gynecological cancers but its role in pancreatic cancer is unclear.

Purpose of the Study:

  • To investigate the expression and function of TMPOP2 in pancreatic cancer.
  • To elucidate the underlying mechanism of TMPOP2's action in pancreatic cancer progression.

Main Methods:

  • Analysis of TMPOP2 expression in The Cancer Genome Atlas (TCGA) and GTEx databases, patient tissues, and cell lines.
  • Functional assays involving TMPOP2 knockdown using small interfering RNA (siRNA).
  • Western blot analysis to assess the phosphorylation of c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (STAT3).

Main Results:

  • TMPOP2 was significantly upregulated in pancreatic cancer tissues and cell lines.
  • TMPOP2 knockdown inhibited pancreatic cancer cell migration and epithelial-mesenchymal transition (EMT).
  • TMPOP2 downregulation inactivated the JNK/STAT3 signaling pathway, and JNK activation partially reversed the inhibitory effects.

Conclusions:

  • TMPOP2 promotes pancreatic cancer progression by enhancing cell migration and EMT via the JNK/STAT3 pathway.
  • TMPOP2 represents a potential therapeutic target for pancreatic cancer treatment.
Keywords:
JNKSTAT3 proteinTMPOP2epithelial-mesenchymal transitionlncRNAmigrationpancreatic cancer

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