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Updated: Jul 23, 2025
Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
Published on: February 7, 2014
Derivation of an Outcome-Driven Threshold for Aortic Pulse Wave Velocity: An Individual-Participant Meta-Analysis
De-Wei An1,2,3, Tine W Hansen2,4, Lucas S Aparicio5
1Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (D.-W.A., Q.-F.H., Y. B.C., C. S.S., J. G.W., Y.L.).
A new outcome-driven threshold for aortic pulse wave velocity (PWV) of 9 m/s predicts cardiovascular events and total mortality. This finding can guide clinical management of arterial stiffness and associated risks.
Area of Science:
- Cardiovascular research
- Arterial biomechanics
- Risk stratification
Background:
- Aortic pulse wave velocity (PWV) is a predictor of cardiovascular events (CVEs) and total mortality (TM).
- Previous studies on actionable PWV thresholds lack generalizability.
- This study defines and validates an outcome-driven PWV threshold.
Conclusions:
- An outcome-driven PWV threshold of 9 m/s is established.
- This threshold predicts cardiovascular events and total mortality.
- Exceeding this PWV threshold warrants stringent risk factor management, particularly hypertension.
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