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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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Neuropathy in prediabetes.

Dan Ziegler1, Christian Herder1,2,3, Nikolaos Papanas4

  • 1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.

Diabetes/Metabolism Research and Reviews
|July 20, 2023
PubMed
Summary
This summary is machine-generated.

Prediabetes, a state of elevated blood glucose, is linked to an increased risk of peripheral neuropathy and cardiovascular disease. Lifestyle interventions may help prevent or delay these conditions.

Keywords:
cardiovascular autonomic neuropathydistal sensorimotor polyneuropathyimpaired fasting glucoseimpaired glucose toleranceprediabetestype 2 diabetes

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Area of Science:

  • Endocrinology and Neurology
  • Public Health

Background:

  • Diabetic neuropathies are major diabetes complications, causing significant morbidity and mortality.
  • Prediabetes affects millions globally, often undiagnosed, and is increasingly recognized as a risk factor for cardiovascular disease (CVD) and mortality.

Purpose of the Study:

  • To review current evidence on the association between prediabetes and peripheral neuropathies.
  • To discuss the potential benefits of lifestyle interventions for prediabetes-related neuropathies.

Main Methods:

  • Review of population-based studies and existing literature.
  • Analysis of evidence linking prediabetes to distal sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN).

Main Results:

  • Growing evidence supports an increased risk of DSPN and CAN in individuals with prediabetes.
  • Lifestyle interventions effective in delaying diabetes progression may also benefit prediabetic neuropathies.

Conclusions:

  • Increased awareness and clinical translation of prediabetes-associated neuropathies are crucial.
  • Screening for prediabetes and implementing preventive interventions can mitigate risks of CVD and neuropathy.