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Thermal-controlled cellular uptake of "hot" nanoparticles
Haibo Chen1, Xuewei Dong1, Luping Ou1
1Center for Soft Condensed Matter Physics and Interdisciplinary Research & School of Physical Science and Technology, Soochow University, Suzhou 215006, Jiangsu, China. yuanbing@sslab.org.cn.
Irradiated nanoparticles interact with cell membranes in a temperature-dependent manner, influencing cellular uptake. This study reveals thermal regulation of nanoparticle-membrane interactions, crucial for photothermal therapy applications.
Area of Science:
- Biomedical Engineering
- Computational Biophysics
- Materials Science
Background:
- Nanoparticles (NPs) show promise in photothermal therapy for precise tumor treatment.
- The molecular mechanisms of irradiated NP cellular uptake remain unclear.
Purpose of the Study:
- Investigate the interaction between heated NPs and model cell membranes.
- Elucidate the thermal regulation of NP-membrane interactions and cellular uptake.
Main Methods:
- Nonequilibrium coarse-grained molecular dynamics simulations.
- Utilized the implicit-solvent Dry Martini force field.
- Simulated interactions with DPPC or DOPC lipid bilayers at temperatures from 270 to 360 K.
Main Results:
- NP-membrane interaction is thermally regulated, with membrane wrapping showing a step-like change with NP temperature.
- Heat conduction from NPs to lipids drives membrane deformation and wrapping, potentially inducing gel-to-fluid phase transitions.
- Lipid leaflets exhibit asymmetric responses to heat flux, affecting lipid packing and interdigitation.
- Thermal wrapping depends on NP properties (size, affinity) and lipid type.
Conclusions:
- Findings provide insights into thermal-regulated NP cellular internalization.
- Offers strategies for modulating NP endocytosis by controlling heating and NP characteristics.
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