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Fibrotic Burden in Patients With Hepatitis B Virus-Related Cirrhosis Is Independently Associated With Poorer Kidney

Chan-Young Jung1,2, Hui-Yun Jung1, Hyung Woo Kim1

  • 1Department of Internal Medicine, Yonsei University College of Medicine.

The Journal of Infectious Diseases
|July 20, 2023
PubMed

Insights

Higher liver fibrosis in hepatitis B virus (HBV)-related cirrhosis patients is linked to worse kidney outcomes. This finding highlights the importance of assessing fibrotic burden for kidney health in this population.

Area of Science:

  • Hepatology
  • Nephrology
  • Gastroenterology

Background:

  • Hepatitis B virus (HBV)-related cirrhosis poses significant health risks.
  • Kidney complications are a concern in patients with liver cirrhosis.
  • The independent association between fibrotic burden and kidney outcomes requires clarification.

Purpose of the Study:

  • To investigate if higher fibrotic burden is independently associated with poorer kidney outcomes.
  • To assess the risk of developing chronic kidney disease (CKD) in HBV-related cirrhosis patients.
  • To determine the impact of liver stiffness on kidney health progression.

Main Methods:

  • A cohort of 1691 patients with HBV-related cirrhosis and no baseline CKD was analyzed.
  • Transient elastography (TE) was used to assess liver fibrotic burden.
  • Kidney outcomes included incident CKD, eGFR decline, end-stage kidney disease, and all-cause mortality.

Main Results:

  • Patients with higher fibrotic burden (liver stiffness ≥11.7 kPa) showed a 2.77-fold increased risk of poorer kidney outcomes.
  • These associations remained significant after adjusting for confounders.
  • The study followed 1691 patients for a median of 5.2 years.

Conclusions:

  • Higher fibrotic burden, assessed by TE, is independently associated with poorer kidney outcomes in HBV-related cirrhosis.
  • Fibrotic burden is a significant predictor of kidney disease progression in this patient group.
  • Early assessment of liver fibrosis may aid in predicting and managing kidney complications.
Abstract

Keywords:
antiviral therapyhepatitis B viruskidney outcomeliver fibrosistransient elastography

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