Related Experiment Video
Updated: Jul 23, 2025
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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
Published on: July 25, 2019
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The ubiquitin codes in cellular stress responses.
Xiangpeng Sheng1,2,3, Zhixiong Xia1,2, Hanting Yang4
1Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China.
Protein & Cell
|July 20, 2023
Summary
Ubiquitination, a key cellular process, is vital for stress responses in mammals. This modification regulates adaptation, recovery, and survival under various cellular stresses.
Area of Science:
- Cellular Biology
- Biochemistry
- Molecular Biology
Background:
- Ubiquitination/ubiquitylation is a fundamental post-translational modification regulating eukaryotic cellular processes.
- Cellular components undergo ubiquitination upon exposure to diverse stresses, leading to varied functional outcomes.
- Ubiquitin signals, or ubiquitin codes, are integral to cellular stress responses.
Conclusions:
- Ubiquitination is a central regulator of cellular adaptation and survival under stress.
- Understanding the ubiquitin system's role in stress is crucial for comprehending cellular resilience.
- Further investigation into ubiquitination machinery and stress responses is warranted.
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