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Updated: Jul 23, 2025
Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
Large-scale lipidomics profiling reveals characteristic lipid signatures associated with an increased cardiovascular
Tobias Harm1, Kristina Dittrich2, Adrian Brun2
1Department of Cardiology and Angiology, University Hospital Tübingen, Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Germany.
Insights
Altered platelet lipids in cardiovascular disease patients indicate a higher risk of adverse events. These specific lipid changes may improve cardiovascular risk assessment and patient classification.
Area of Science:
- Cardiovascular Medicine
- Lipidomics
- Platelet Biology
Background:
- Cardiovascular disease (CVD) patients face high risks of adverse events, not fully explained by traditional factors.
- Platelets are crucial in CVD progression; hyperreactivity contributes to adverse cardiovascular (CV) events.
- Altered platelet lipidomes can cause hyperresponsiveness, potentially modifying individual risk profiles.
Purpose of the Study:
- Investigate the platelet lipidome in coronary artery disease (CAD) patients using untargeted lipidomics.
- Identify alterations in lipid composition associated with adverse CV events in CAD patients.
Main Methods:
- Characterized the platelet lipidome in a large CAD cohort (n=1057).
- Employed untargeted lipidomics via liquid chromatography-mass spectrometry.
Main Results:
- Identified 767 lipids, with characteristic changes in patients experiencing adverse CV events.
- Prominent upregulated lipids in patients with CV events were phospholipids and fatty acyls.
- Upregulated platelet lipids correlated with increased CV or bleeding risk and independently predicted adverse events, modulating in vitro platelet functions.
Conclusions:
- Platelet lipidome composition is altered in CVD patients with elevated cardiovascular risk.
- Specific platelet lipids may serve as indicators for adverse CV events.
- Findings may enhance risk discrimination and classification for cardiovascular events in CVD patients.
Background And Aims:
Patients with cardiovascular disease (CVD) are at high risk to develop adverse events. The distinct risk of developing adverse cardiovascular (CV) events is not solely explained by traditional risk factors. Platelets are essentially involved in progression of CVD including coronary artery disease (CAD) and platelet hyperreactivity leads to development of adverse CV events. Alterations in the platelet lipidome lead to platelet hyperresponsiveness and thus might alter the individual risk profile. In this study, we investigate the platelet lipidome of CAD patients by untargeted lipidomics and elucidate alterations in the lipid composition of patients with adverse CV events.
Methods:
We characterized the platelet lipidome in a large consecutive CAD cohort (n = 1057) by an untargeted lipidomics approach using liquid chromatography coupled to mass spectrometry.
Results:
The platelet lipidome in this study identified 767 lipids and characteristic changes occurred in patients with adverse CV events. The most prominent upregulated lipids in patients with cardiovascular events primarily belong to the class of phospholipids and fatty acyls. Further, upregulated platelet lipids are associated with an increased cardiovascular or bleeding risk and independently associated with adverse events. In addition, alterations of the platelet lipidome are associated with modulation of in vitro platelet functions.
Conclusions:
Our results reveal that the composition of the platelet lipidome is altered in CVD patients with an increased cardiovascular risk and distinct platelet lipids may indicate adverse events. Results of this study may contribute to improved risk discrimination and classification for cardiovascular events in patients with CVD. Main findings of this study and hypothetical impact of altered platelet lipid signatures in patients with adverse cardiovascular events on platelet function and clinical outcome. LPE lysophosphatidylethanolamines, CAR acylcarnitines, FA fatty acids.
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