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Updated: Jul 22, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
Teaching of drug disposition using physiologically based pharmacokinetic modeling software: GastroPlus as an
Noam Morningstar-Kywi1,2, Denise N Morris2, Rebecca M Romero1
1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Los Angeles, California, United States.
Abstract:
Physiologically based pharmacokinetic (PBPK) modeling requires an understanding of chemical, physiologic, and pharmacokinetic principles. Active learning with PBPK modeling software (GastroPlus) may be useful to teach these scientific principles while also teaching software operation. To examine this issue, a graduate-level course was designed using learning objectives in science, software use, and PBPK model application. These objectives were taught through hands-on PBPK modeling to answer clinically relevant questions. Students demonstrated proficient use of software, based on their responses to these questions, and showed an improved understanding of scientific principles on a pre- and post-course assessment. These outcomes support the effectiveness of simultaneous teaching of interdependent software and science.NEW & NOTEWORTHY Physiologically based pharmacokinetic (PBPK) modeling is a major growth area in drug development, regulatory submissions, and clinical applications. There is a demand for experts in this area with multidisciplinary backgrounds. In this article, we describe a course designed to teach PBPK modeling and the underlying scientific principles in parallel.
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