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PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure...
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Innovate beyond PFAS.

Martin Scheringer1

  • 1Martin Scheringer is a professor of environmental chemistry at RECETOX, Masaryk University, Brno, Czech Republic, and a senior scientist and group leader at ETH Zürich, Zürich, Switzerland. He is also the chair of the International Panel on Chemical Pollution and a co-coordinator of the Global PFAS Science Panel.

Science (New York, N.Y.)
|July 20, 2023
PubMed
Summary
This summary is machine-generated.

New legislation addresses per- and polyfluoroalkyl substances (PFAS), or "forever chemicals," due to widespread environmental contamination. Evolving regulations aim to manage the risks posed by these persistent chemicals in consumer products and drinking water.

Area of Science:

  • Environmental Science
  • Regulatory Affairs
  • Toxicology

Background:

  • Per- and polyfluoroalkyl substances (PFAS) are widely used in consumer products.

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  • PFAS are persistent environmental pollutants found in food, water, and the human body.
  • Current regulations for PFAS are complex and evolving globally.