Recent advances towards mass spectrometry-based clinical lipidomics

Area of Science:

• Biochemistry
• Clinical Research
• Analytical Chemistry

Background:

• Lipidomics is increasingly vital in clinical research.
• Understanding lipid profiles aids in disease prediction and monitoring.

Purpose of the Study:

• To review recent advancements in lipidomics methodologies for clinical research.
• To highlight emerging patterns and future directions in the field.

Main Methods:

• Assessment of high-selectivity and high-sensitivity lipidomics techniques.
• Evaluation of innovations in microsampling for clinical applications.
• Analysis of studies demonstrating the utility of molecular lipid signatures.

Main Results:

• Advanced lipidomics methods can analyze numerous lipid species from small samples.
• Molecular lipid signatures show promise for precision medicine, disease prediction, and monitoring.
• Microsampling techniques offer significant potential for clinical lipidomics.

Conclusions:

• Further work is required to harmonize lipidomics platforms and reporting standards.
• Increased use of internal standards and reference materials is crucial for accuracy.
• Lipidomics holds substantial promise for advancing clinical diagnostics and personalized medicine.