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Lateralization

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.

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Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

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Thalamic asymmetry in Multiple Sclerosis.

Neda Ramezani¹, Fariba Davanian², Saba Naghavi³

¹Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Center for Translational Neuroscience, Isfahan University of Medical Sciences, Isfahan, Iran.

Multiple Sclerosis and Related Disorders

|July 20, 2023

Summary

Thalamic asymmetry in Multiple Sclerosis (MS) is linked to disease progression and subtype. Healthy individuals show less thalamic asymmetry than MS patients, with differences observed between relapse-remitting MS and secondary progressive MS.

Keywords:

Asymmetry Atrophy Brain asymmetry Computer-assisted Image processing Magnetic resonance imaging Multiple Sclerosis Thalamic asymmetry Thalamus

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Last Updated: Jul 22, 2025

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Area of Science:

Neuroimaging
Neurology
Medical research

Background:

Multiple Sclerosis (MS) is a chronic neuroinflammatory condition impacting the central nervous system.
Brain MRI findings, including asymmetry, are associated with debilitating MS symptoms.
Thalamic asymmetry is a key area of investigation in understanding MS pathology.

Purpose of the Study:

To investigate and compare thalamic asymmetry in MS patients.
To explore the relationship between thalamic asymmetry and other MRI and clinical findings in MS.
To differentiate thalamic asymmetry patterns across MS subtypes and healthy controls.

Main Methods:

Cross-sectional study involving 83 relapse-remitting MS (RRMS), 43 secondary progressive MS (SPMS) patients, and 89 healthy controls.
Calculation of intracranial, gray matter, white matter, lesion, and thalamic volumes.
Assessment of thalamic asymmetry indices (TAI), 9-hole peg test (9-HPT), and Expanded Disability Status Scale (EDSS).

Main Results:

Normalized whole thalamic volume was higher in healthy subjects than in both RRMS and SPMS patients.
Thalamic asymmetry index (TAI) differed significantly between RRMS and SPMS patients (p=0.011).
Absolute TAI was significantly lower in healthy subjects compared to RRMS (p<0.001) and SPMS (p<0.001) patients, with higher absolute TAI in SPMS versus RRMS (p=0.037).

Conclusions:

A relationship exists between normalized whole thalamic volume and MS subtype.
Thalamic asymmetry indices correlate with disease progression in MS.
Thalamic asymmetry is linked to disease progression and subtype variations in Multiple Sclerosis.