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Updated: Jul 22, 2025
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
One pot preparation of muti-mode nanoplatform to combat ovarian cancer
Xiuliang Dai1, Lingjun Li1, Minhui Li1
1Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, China.
Abstract:
Ovarian cancer is one of the most common gynecological cancers with high mortality rate. The battle against ovarian cancer usually impaired by the evolved multidrug resistance (MDR) phenotype as well as metastasis in cancers, which urgently call for the development of multi-mode strategies to overcome the MDR and reduce metastasis. Considering the good benefits of ferroptosis and photothermal therapy (PTT) in cancer management, we herein proposed a facile way to construct nanoparticle platform (Fe-Dox/PVP) composed of ferric chloride, doxorubicin (Dox) and polyvinyl pyrrolidone (PVP) for the multi-mode therapy of ovarian cancer using chemotherapy, ferroptosis and mild hypothermia PTT. Our results demonstrated that Fe-Dox/PVP with mild hypothermia was shown to have improved endosomal escape/drug delivery, enhanced ferroptosis induction and good tumor targeting effects. Most importantly, the integration of all three effects into one platform provided increased anti-metastasis effect and promising in vitro/in vivo anticancer performance with high biocompatibility. In this study, we offer a facile and robust way to prepare a multi-mode nanoplatform to combat ovarian cancer, which can be further extended for the management of many other cancers.
Insights
This study introduces a novel nanoparticle platform for ovarian cancer treatment, combining chemotherapy, ferroptosis, and mild photothermal therapy (PTT). This multi-modal approach effectively combats multidrug resistance and metastasis with high biocompatibility.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Ovarian cancer presents a high mortality rate, often exacerbated by multidrug resistance (MDR) and metastasis.
- Current treatments struggle to overcome these challenges, necessitating innovative therapeutic strategies.
Purpose of the Study:
- To develop a versatile nanoparticle platform for multi-modal ovarian cancer therapy.
- To integrate chemotherapy, ferroptosis induction, and mild photothermal therapy (PTT) into a single system.
Main Methods:
- Fabrication of a nanoparticle platform (Fe-Dox/PVP) using ferric chloride, doxorubicin (Dox), and polyvinyl pyrrolidone (PVP).
- Evaluation of the platform's efficacy in vitro and in vivo, assessing endosomal escape, drug delivery, ferroptosis induction, tumor targeting, and anti-metastasis effects.
Main Results:
- The Fe-Dox/PVP nanoparticles demonstrated improved endosomal escape and drug delivery under mild hypothermia.
- Enhanced ferroptosis induction and effective tumor targeting were observed.
- The integrated approach significantly reduced metastasis and showed promising anticancer performance with high biocompatibility.
Conclusions:
- The Fe-Dox/PVP nanoparticle platform offers a facile and robust method for multi-modal ovarian cancer treatment.
- This strategy effectively overcomes MDR and metastasis, showing potential for broader application in cancer management.
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