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Updated: Jul 22, 2025

Intraoperative Ultrasound in Spinal Surgery
Published on: August 17, 2022
Bing-Neel syndrome with a paravertebral mass
Daisuke Suzuki1, Daisuke Sato1, Kenji Kikuchi1
1Department of Neurology, Nihonkai General Hospital, Sakata, Yamagata, Japan.
Abstract:
Bing-Neel syndrome, a rare neurological complication of Waldenström macroglobulinemia, is caused by the direct infiltration of malignant lymphoplasmacytic cells into the central nervous system. We report a patient who presented with back pain, weakness, lower extremity numbness, and gait disturbance accompanied by immunoglobulin M paraproteinemia and lymphoplasmacytic lymphoma in the bone marrow. Thoracic and lumbar magnetic resonance imaging revealed a long paravertebral mass around the spinal column, but the direct infiltration could not be proven. The patient was diagnosed with possible Bing-Neel syndrome and managed with bendamustine and rituximab. After chemotherapy, the patient's neurological and radiological findings improved. Magnetic resonance imaging should be considered when the Bing-Neel syndrome diagnosis is unclear.

