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The hidden dangers of chronic pancreatitis in pregnancy: Evidence from a large-scale population study

Chengu Niu1, Jing Zhang2, Kaiwen Zhu1

  • 1Internal Medicine Residency Program, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|July 20, 2023
PubMed

Insights

Chronic pancreatitis in pregnant women increases risks for gestational diabetes, hypertensive complications, preterm labor, and fetal death. This highlights the need for careful preconception counseling and management.

Area of Science:

  • Obstetrics and Gynecology
  • Gastroenterology
  • Public Health

Background:

  • Chronic pancreatitis affects women of childbearing age, with poorly understood maternal and perinatal outcome impacts.
  • Limited data exists on the risks associated with pregnancy in women with chronic pancreatitis.

Purpose of the Study:

  • To investigate maternal and perinatal outcomes in pregnancies complicated by chronic pancreatitis.
  • To inform healthcare providers for better counseling and clinical decision-making.

Main Methods:

  • Retrospective analysis of hospital discharge records from the National Inpatient Sample database (2009-2019).
  • Investigation of primary maternal and perinatal outcomes.

Main Results:

  • Chronic pancreatitis is associated with increased rates of gestational diabetes (AOR 1.63) and gestational hypertensive complications (AOR 2.48).
  • Pregnancies with chronic pancreatitis show higher likelihood of preterm labor (AOR 3.10) and small for gestational age (AOR 2.40).
  • Alcohol-induced chronic pancreatitis poses a higher risk of fetal death (OR 17.15); chronic renal failure increases risk of gestational hypertension (OR 20.09). Longer hospital stays and costs were also noted.

Conclusions:

  • Chronic pancreatitis significantly heightens risks for adverse maternal and fetal outcomes.
  • Findings underscore the critical need for preconception counseling for women with chronic pancreatitis.
  • Healthcare providers should be aware of these elevated risks to optimize patient care.
Abstract

Keywords:
FetusMotherNational inpatient sample databaseOutcomes

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