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RDN for the treatment of influenza in children: a randomized, double-blinded, parallel-controlled clinical trial

Shuo Yang1,2, Yan-Ming Xie3,4, Lian-Xin Wang5,6

  • 1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

BMC Complementary Medicine and Therapies
|July 20, 2023
PubMed

Insights

Reduning injection (RDN) shows promise as a safe and effective treatment for pediatric influenza, offering an alternative to Oseltamivir. This study evaluates RDN

Area of Science:

  • Pediatric infectious diseases
  • Pharmacology
  • Traditional Chinese Medicine

Background:

  • Influenza morbidity in children has risen.
  • Reduning injection (RDN) is a Chinese herbal formula with antipyretic, antiviral, and anti-inflammatory properties.
  • Evaluating RDN for pediatric influenza is crucial.

Purpose of the Study:

  • To assess the efficacy and safety of RDN compared to Oseltamivir for pediatric influenza.
  • To explore the antiviral mechanisms of RDN.
  • To provide evidence for rational clinical use of RDN.

Main Methods:

  • Randomized, double-blind, double-dummy, multi-center clinical trial.
  • 240 pediatric patients with influenza randomized 1:1 to RDN or Oseltamivir.
  • Primary outcome: temperature recovery time; secondary outcomes: fever subsidence, symptom alleviation, symptom disappearance.

Main Results:

  • Temperature recovery time was the primary outcome measure.
  • Secondary outcomes included fever subsidence and symptom alleviation.
  • Data collected pre-enrollment and every 24 hours post-treatment.

Conclusions:

  • The study aims to evaluate RDN's efficacy and safety in children with influenza.
  • RDN may offer an alternative treatment option for pediatric influenza.
  • Evidence-based data will support clinical drug usage.
Abstract

Keywords:
Efficacy and safetyInfluenza in childrenReduning injectionTime of temperature recovery

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