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Multi-omics in thoracic aortic aneurysm: the complex road to the simplification.
Sara Rega1,2, Floriana Farina3,4, Silvia Bouhuis1
1Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, Italy.
Cell & Bioscience
|July 20, 2023
Summary
Thoracic aortic aneurysm (TAA) research uses multi-omics to uncover disease mechanisms. Integrating these findings offers new diagnostic and therapeutic targets for this complex condition.
Area of Science:
- Biochemistry
- Genomics
- Proteomics
- Metabolomics
Background:
- Thoracic aortic aneurysm (TAA) is a life-threatening condition involving aortic dilation with complex, heterogeneous causes.
- Current treatments for TAA are palliative, lacking etiological therapies.
- Advanced -omics techniques are crucial for identifying TAA's biological targets and mechanisms.
Purpose of the Study:
- To review recent findings from -omics approaches in TAA research.
- To emphasize the importance of integrating multi-omics data for a comprehensive understanding of TAA.
Main Methods:
- Review of literature utilizing epigenomics, transcriptomics, proteomics, and metabolomics.
- Analysis of integrated multi-omics data for TAA insights.
Main Results:
- TAA alterations involve pro-fibrotic processes (TGF-β signaling) and cell structure proteins (aggrecans).
- Key processes in TAA include inflammation, oxidative stress, mitochondrial respiration, and glycolysis.
- Metabolomics studies identified novel detrimental mediators like proteoglycans in TAA.
Conclusions:
- Integrating multi-omics and clinical data is essential for understanding complex diseases like TAA.
- Metabolomics advancements offer promising new markers for TAA diagnosis and therapy.
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