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Applications of poly(lactic acid) in bone tissue engineering: A review article
Mahya Sadat Alavi1, Sara Memarpour1, Hadis Pazhohan-Nezhad2
1Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Artificial Organs
|July 21, 2023
Summary
Poly Lactic acid (PLA) scaffolds show promise for bone tissue engineering but have limitations. Combining PLA with other biomaterials enhances osteogenesis and bone repair, overcoming its drawbacks for improved bone regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedic Surgery
Background:
- Bone tissue engineering utilizes scaffolds and osteoblasts for bone regeneration.
- Scaffolds mimic natural bone properties using various biomaterials.
Purpose of the Study:
- Review Poly Lactic acid (PLA) applications in bone regeneration.
- Discuss modifications to PLA to enhance osteogenesis and bone repair.
Main Methods:
- Literature review of Poly Lactic acid (PLA) applications.
- Analysis of PLA modifications for bone tissue engineering.
Main Results:
- Poly Lactic acid (PLA) is suitable for scaffolds due to processability and biocompatibility.
- PLA has limitations: low osteoconductivity, poor cell adhesion, and potential inflammation.
- Combining PLA with other biomaterials addresses these limitations.
Conclusions:
- Poly Lactic acid (PLA) is a versatile material for bone regeneration scaffolds.
- Modifications and composite strategies improve PLA's efficacy in bone repair.
- Further research into PLA-based composites is warranted for advanced bone tissue engineering.
