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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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Emerging roles of microRNAs in septic cardiomyopathy

Mingyan Wu1, Guangdong Li1, Wenjun Wang1

  • 1Department of Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Frontiers in Pharmacology
|July 21, 2023
PubMed

Insights

Septic cardiomyopathy, a serious sepsis complication, has poor treatment outcomes. MicroRNAs show promise as novel therapeutic targets by regulating immunity and cell death in septic cardiomyopathy.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Cardiology

Background:

  • Septic cardiomyopathy is a severe complication of sepsis, characterized by high morbidity and mortality.
  • Current clinical treatments for septic cardiomyopathy lack efficacy due to the absence of precise therapeutic targets.

Purpose of the Study:

  • To review the critical role of microRNAs in the pathogenesis, diagnosis, and treatment of septic cardiomyopathy.
  • To explore microRNAs as potential novel therapeutic targets for septic cardiomyopathy.

Main Methods:

  • Literature review of studies investigating microRNAs in septic cardiomyopathy.
  • Analysis of microRNA-mediated regulation of immunity and programmed cell death in the context of sepsis.

Main Results:

  • MicroRNAs are implicated in the development and progression of septic cardiomyopathy.
  • MicroRNAs regulate key pathways including immune response and programmed cell death relevant to septic cardiomyopathy.

Conclusions:

  • MicroRNAs represent promising biomarkers for diagnosing septic cardiomyopathy.
  • Targeting microRNAs offers a novel therapeutic strategy for improving outcomes in septic cardiomyopathy.
Keywords:
apoptosisautophageinflammationmicroRNApyroptosisseptic cardiomyopathy

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