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Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

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Gene expression analysis in recurrent benign paroxysmal positional vertigo: a preliminary study.

Eun Hye Oh¹, Jin-Ok Lee², Hyun Sung Kim³

¹Department of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Frontiers in Neurology

|July 21, 2023

Summary

Recurrent benign paroxysmal positional vertigo (BPPV) in young patients may stem from oxidative stress and immune responses. Gene expression analysis reveals key pathways linked to inflammation and tissue degradation in BPPV development.

Keywords:

benign paroxysmal positional vertigo (BPPV)bioinformatics analysis gene expression profiling (GEP)immune system oxidative stress

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Published on: February 21, 2018

Area of Science:

Genomics
Bioinformatics
Otolaryngology

Background:

Recurrent benign paroxysmal positional vertigo (BPPV) pathophysiology in young individuals remains unclear.
Understanding genetic underpinnings is crucial for targeted therapeutic strategies.

Purpose of the Study:

To investigate the molecular mechanisms of recurrent BPPV in young patients.
To identify differentially expressed genes (DEGs) and associated pathways using gene expression profiling and bioinformatics.

Main Methods:

Whole blood RNA extraction from young BPPV patients and controls.
Microarray analysis to identify DEGs (|log2 fold change| > 1, adjusted p < 0.05).
Gene Ontology and protein-protein interaction (PPI) network analysis.

Main Results:

Identified 39 DEGs (33 upregulated, 6 downregulated) in BPPV patients.
Upregulated DEGs enriched in metabolic and immune system processes.
Key pathways identified: oxidative phosphorylation/stress and adaptive immunity/ECM degradation.

Conclusions:

Bioinformatics analysis suggests oxidative stress and ECM degradation contribute to recurrent BPPV.
Immune-mediated inflammatory responses may play a role in BPPV pathogenesis.
Findings offer insights into the molecular basis of BPPV in young populations.