"InMotion"-Mixed physical exercise program with creative movement as an intervention for adults with schizophrenia:...

Area of Science:

• Psychiatry and Neuroscience
• Rehabilitation Medicine
• Clinical Psychology

Background:

• Schizophrenia is a leading cause of long-term disability worldwide, significantly impairing social and occupational functioning.
• Antipsychotic medications are standard treatment, but complementary therapies are needed to address functional deficits.
• Physical training and psychosocial interventions show promise as adjuncts to standard care.

Purpose of the Study:

• To assess the feasibility and effects of a novel, integrated intervention combining physical training with cognitive, emotional, and social stimulation for individuals with schizophrenia.
• To evaluate the intervention's impact on clinical symptoms, quality of life, social performance, and neurophysiological measures.

Main Methods:

• A 12-week mixed-method randomized controlled trial involving 60 adults with schizophrenia (30 intervention, 30 standard care).
• The intervention included 24 biweekly 60-minute sessions combining aerobic/strength training with psychosocial elements.
• Assessments included clinical measures (PANSS), quality of life, social performance, movement, brain function, and eye-tracking, with qualitative interviews for a subgroup.

Main Results:

• Pilot data collection concluded June 2023; main data collection began September 2023.
• Full results are anticipated following the final follow-up in 2026.
• The study is registered under ClinicalTrials.gov identifier NCT05673941.

Conclusions:

• The InMotion study aims to provide novel insights into the feasibility, efficacy, and patient experience of an integrated intervention for schizophrenia.
• The hypothesis posits that the intervention will reduce symptoms, normalize brain function, and foster active habits.
• Findings are expected to inform the development of more comprehensive treatment strategies for schizophrenia.