Digital therapeutics in the clinic

Area of Science:

• Digital health
• Medical informatics
• Therapeutic technologies

Background:

• Digital therapeutics (DTx) represent a novel class of interventions utilizing software to deliver evidence-based treatments.
• DTx can be delivered via web or mobile applications, virtual reality, or video games, offering versatile therapeutic modalities.
• These digital interventions are recognized as a distinct product category by the FDA, allowing for stand-alone or adjunctive use with conventional therapies.

Purpose of the Study:

• To provide a comprehensive review of the clinical landscape of digital therapeutics.
• To summarize currently FDA-approved digital therapeutic products and their clinical applications.
• To overview the >300 ongoing clinical trials in the digital therapeutics space.

Main Methods:

• Systematic review of the clinical literature on digital therapeutics.
• Analysis of FDA-approved digital therapeutic products and their indications.
• Survey of ongoing clinical trials investigating digital therapeutics across various disease areas.

Main Results:

• Summary of FDA-approved digital therapeutics, detailing their specific clinical uses.
• Overview of over 300 ongoing clinical trials, highlighting the expanding research in DTx.
• Identification of key challenges hindering the clinical translation of digital therapeutics.

Conclusions:

• Digital therapeutics are a rapidly growing field with significant potential to treat, manage, and prevent diseases.
• Addressing challenges in clinical translation is crucial for the widespread adoption and success of digital therapeutics.
• Further research and strategic implementation are needed to overcome barriers and maximize the benefits of DTx in healthcare.