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Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
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Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Abdominal Aorta01:25

Abdominal Aorta

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Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
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Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

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IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
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Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
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Related Experiment Video

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Porcine Model of Infrarenal Abdominal Aortic Aneurysm
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IL-1 in Abdominal Aortic Aneurysms.

Jessica Millar1, Elias Nasser2, Gorav Ailawadi2,3

  • 1Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Journal of Cellular Immunology
|July 21, 2023
PubMed
Summary

Abdominal Aortic Aneurysms (AAA) involve inflammation driven by Interleukin-1 (IL-1). Targeting IL-1 shows promise for future AAA therapeutic strategies.

Keywords:
AAAAnakinraIL-1αIL-1β

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Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Vascular Medicine

Background:

  • Abdominal Aortic Aneurysms (AAA) are a significant cause of mortality with no effective medical treatments.
  • AAA pathogenesis involves inflammation, smooth muscle cell apoptosis, and matrix degradation.
  • Interleukin-1 (IL-1) is implicated in AAA inflammation via immune cell recruitment, endothelial dysfunction, and ROS production.

Purpose of the Study:

  • To review the role of IL-1 signaling in AAA pathogenesis.
  • To discuss regulators of IL-1 signaling relevant to AAA.
  • To explore the therapeutic potential of IL-1 inhibition in experimental AAAs.

Main Methods:

  • Review of existing literature on IL-1 signaling and AAA.
  • Analysis of studies investigating IL-1's role in AAA-associated inflammation.
  • Examination of data on genetic and pharmacological IL-1 inhibition in experimental AAA models.

Main Results:

  • IL-1 signaling pathways are central to AAA-induced inflammation.
  • Modulation of IL-1 signaling impacts AAA progression in experimental models.
  • Genetic and pharmacological inhibition of IL-1 demonstrates therapeutic potential.

Conclusions:

  • Interleukin-1 (IL-1) is a key mediator of inflammation in Abdominal Aortic Aneurysms (AAA).
  • Targeting IL-1 signaling presents a promising therapeutic avenue for managing AAA disease.
  • Further research into IL-1 inhibitors could lead to effective AAA treatments.