Related Experiment Video
Updated: Jul 22, 2025

Porcine Model of Infrarenal Abdominal Aortic Aneurysm
Published on: November 21, 2019
IL-1 in Abdominal Aortic Aneurysms
Jessica Millar1, Elias Nasser2, Gorav Ailawadi2,3
1Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Abstract:
Abdominal Aortic Aneurysms (AAA) remain a clinically devastating disease with no effective medical treatment therapy. AAAs are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. Interleukin-1 (IL-1) has been shown to play role in AAA associated inflammation through immune cell recruitment and activation, endothelial dysfunction, production of reactive oxygen species (ROS), and regulation of transcription factors of additional inflammatory mediators. In this review, we will discuss the principles of IL-1 signaling, its role in AAA specific inflammation, and regulators of IL-1 signaling. Additionally, we will discuss the influence of genetic and pharmacological inhibitors of IL-1 on experimental AAAs. Evidence suggests that IL-1 may prove to be a potential therapeutic target in the management of AAA disease.
Related Concept Videos
Aneurysm III: Interprofessional Care
Aneurysm I: Introduction
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Abdominal Aorta
The celiac trunk, a singular artery, divides into the left gastric artery, which...
Aortic Regurgitation I: Introduction
Peripheral Artery Disease I: Introduction

