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Updated: Jul 22, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
Memantine Use and Cognitive Decline in Huntington's Disease: An Enroll-HD Study
Amy C Ogilvie1,2, Jordan L Schultz2,3,4
1Department of Epidemiology The College of Public Health at the University of Iowa Iowa City IA USA.
Background:
Memantine is an N-methyl-d-aspartate (NMDA) receptor antagonist that is used to treat moderate to severe Alzheimer's Dementia (AD) and has been speculated to provide clinical benefits in Huntington's disease (HD).
Objective:
To assess the effectiveness of memantine on the trajectory of cognitive decline in individuals with manifest HD.
Methods:
Using participants from the Enroll-HD study, the primary analysis compared trajectories in cognition over a 5-year period using linear mixed effect models of prevalent and incident memantine users who were propensity-score-matched with non-users on measures of disease progression and demographics.
Results:
In the primary analysis there were no significant differences in the trajectories between memantine users and non-users on any primary outcomes of interest.
Conclusions:
Memantine use was not associated with any clinical benefit for individuals with manifest HD. Further studies are warranted to assess the impact of memantine on clinical outcomes in HD.
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