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Updated: Jul 22, 2025

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Published on: November 28, 2015

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CDC42-A promising immune-related target in glioma

Tao Jiang1,2, Xianwei Wang1, Jiaming Huang1

  • 1Department of Neurosurgery, The Dalian Municipal Central Hospital, Dalian, China.

Frontiers in Neuroscience
|July 21, 2023
PubMed

Insights

Cell division cycle 42 (CDC42) is overactivated in glioma, correlating with poor prognosis and higher tumor malignancy. Targeting CDC42 may offer a new avenue for glioma immunotherapy.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Glioma is a severe central nervous system neoplasm with poor prognosis.
  • Overactivation of cell division cycle 42 (CDC42), a polarity-regulating GTPase, is linked to increased tumor malignancy in various cancers.

Purpose of the Study:

  • To investigate the role and prognostic significance of CDC42 expression in glioma.
  • To explore the association of CDC42 with clinical features, biological functions, and immune infiltration in glioma.

Main Methods:

  • Analysis of CDC42 RNA-seq and protein expression data from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases.
  • Differential expression analysis, survival analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and immune infiltration analysis were performed.
  • Correlation analysis with clinical parameters, including WHO grade, IDH1 status, MGMT methylation, and 1p19q codeletion.

Main Results:

  • CDC42 expression was significantly upregulated in glioma tissues compared to normal controls.
  • Elevated CDC42 levels were strongly associated with poor prognosis and adverse clinical indicators (higher WHO grade, wild-type IDH1, unmethylated MGMT, non-codeleted 1p19q).
  • CDC42 enrichment correlated with immune and inflammatory responses, immune checkpoints, and regulatory T cell markers (CD4, CD25, CD127).

Conclusions:

  • CDC42 is a potential biomarker for predicting poor prognosis in glioma.
  • CDC42 plays a role in regulating the tumor immune microenvironment in glioma.
  • CDC42 represents a promising therapeutic target for glioma immunotherapy.
Keywords:
CDC42bioinformatics analysisgliomaimmune infiltrationsurvival analysis

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