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Research progress on the nucleoside/nucleotide-loaded nanomedicines
Zheng Zhou1,2, Haifang Liu3, Mingzhou Ye4,5
1Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, Jiangsu Province, China. zzhou2022@sinano.ac.cn.
Summary
Nucleoside drugs face limitations like poor bioavailability. Nanocarriers enhance nucleoside drug delivery for treating tumors and viral infections, improving efficacy and targeting.
Area of Science:
- Pharmaceutical Sciences
- Nanomedicine
- Drug Delivery
Background:
- Nucleoside drugs are vital for treating tumors and viral infections but suffer from poor bioavailability, targeting, and cellular uptake.
- These limitations hinder their clinical effectiveness and broad application.
Approach:
- This review explores nanocarrier strategies for improving nucleoside drug delivery.
- It details the design of nanomedicines, focusing on enhancing drug properties and therapeutic outcomes.
- The review also discusses modifications for active targeting and improved cellular penetration.
Key Points:
- Nanocarriers improve nucleoside drug delivery efficiency, bioavailability, and stability.
- They enable better control over drug release and pharmacokinetics.
- Surface modifications on nanocarriers facilitate active targeting of diseased cells.
Conclusions:
- Nanodelivery systems offer a promising strategy to overcome the limitations of conventional nucleoside drugs.
- Further development in nucleoside/nucleotide-loaded nanomedicines holds significant therapeutic potential.
- Optimized nanomedicine design can lead to more effective treatments for major diseases.
