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Updated: Jul 22, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Synthesis of flavones via the Stork-Danheiser reaction
Jianfeng Li1, Ankun Zhou2, Wenping Zhang1
1School of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, 1076 Yuhua Road, Chenggong District, Kunming 650500, Yunnan, P. R. of China. ljf7614phd@163.com.
Abstract:
A new method to access flavones in a convergent fashion has been developed, based on the Stork-Danheiser reaction. By this method, 4-methoxy coumarins are allowed to react with organolithium at low temperatures (-78 °C to -40 °C) and then acidic workup gives the desired flavones in 18-86% yields. This method features transition metal-free conditions, readily available starting materials, and simple operation. It is particularly efficient when rapid generation of B ring flavone derivatives is desired.
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