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[Sperm small non-coding RNAs and intergenerational inheritance].

Qian Liu1, Wen-Bing Zhu1,2,3

  • 1Research Institute of Reproductive and Stem Cell Engineering, School of Basic Medicine, Central South University, Changsha, Hunan 420078, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|July 21, 2023
PubMed
Summary
This summary is machine-generated.

Environmental factors like diet and stress impact offspring development through sperm small non-coding RNAs (sncRNAs), influencing inherited traits across generations. This review examines microRNAs and tRNAs in sperm epigenetics.

Keywords:
sperm; epigenetics; small non-coding RNA

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Area of Science:

  • Reproductive Biology
  • Epigenetics
  • Developmental Biology

Background:

  • Environmental factors (diet, stress) impact offspring development and inherited traits.
  • Sperm small non-coding RNAs (sncRNAs) are affected by environmental stressors.
  • sncRNAs mediate inter-generational inheritance of acquired traits via epigenetic regulation.

Approach:

  • This review focuses on microRNAs (miRNAs) and transfer RNAs (tRNAs) within sperm.
  • Examines the role of sncRNAs in sperm epigenetics.
  • Synthesizes current research on sncRNAs and cross-generational inheritance.

Key Points:

  • Parental environmental exposures can alter sperm sncRNA expression.
  • sncRNAs act as carriers of paternal epigenetic information.
  • miRNAs and tsRNAs are key players in mediating inherited epigenetic modifications.

Conclusions:

  • Sperm sncRNAs are crucial mediators of environmentally induced epigenetic inheritance.
  • Understanding miRNA and tsRNA roles in sperm is vital for reproductive health.
  • Epigenetic modifications via sncRNAs offer insights into acquired trait transmission.