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Updated: Jul 22, 2025

Fluorescence in situ hybridization FISH Protocol in Human Sperm
Published on: September 1, 2009
[Chromosomal structural abnormalities in men with semen abnormality and analysis of 19 cases of first-reported
Mei-Jia Chen1, Fu-Tong Lü A1, Pei Huang1
1Department of Clinical Laboratory, Reproduction Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, China .
Objective:
To investigate the chromosomal structural abnormalities and pregnancy outcomes in men with semen abnormality.
Methods:
We analyzed the karyotype of 3 095 male patients with semen abnormality spermatogenesis, performed pedigree analysis and provided reproduction guidance for those with chromosomal structural abnormalities.
Results:
Of the 3 095 male patients with semen abnormality, 52 (1.68%) cases of chromosomal structural abnormalities were detected, including 28 cases of balanced translocation, 21 cases of Robertsonian translocation and 3 cases of chromosome inversion. There were 19 cases of rare abnormal karyotype first reported in the world.
Conclusion:
Reciprocal translocation is a main type of chromosomal structural abnormality in male patients with semen abnormality. An insight into the types of chromosomal abnormalities and analysis of the heredity of chromosomes in a family may help detect chromosomal abnormality carriers and provide scientific reproduction guidance.
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