Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

254
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
254
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

99
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
99
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

157
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
157
Assessment of the Rectum and Anus01:25

Assessment of the Rectum and Anus

279
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
279
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

220
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
220
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

296
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
296

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thoracoabdominal Normothermic Regional Perfusion Safely Preserves the Irreversibility of Death in a Pediatric Porcine DCD Model: Combined Cerebrovascular Doppler and Intracortical EEG Evidence.

Transplantation·2026
Same author

Effects of Cold Preservation on Intestinal Grafts from Donation after Circulatory Death and Brain Death Donors in an Experimental Model.

The Journal of surgical research·2026
Same author

Clinical Applications of Indocyanine Green Fluorescence Imaging in Vascular Malformations: A Systematic Review.

Journal of clinical medicine·2026
Same author

Pediatric Pilonidal Disease Surgical Approach (PPiDSA) Study.

Children (Basel, Switzerland)·2026
Same author

Revolutionizing small bowel transplantation in mice and rats: A cutting-edge dry-lab simulation model.

Current problems in surgery·2025
Same author

Robotic-assisted thoracic surgery in children: A systematic review and meta-analysis.

Journal of pediatric surgery·2025

Related Experiment Video

Updated: Jul 22, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
00:08

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.1K

Mucosal appendicitis: How can it be differentiated from nonappendicitis?

Carlos Delgado-Miguel1,2,3, Miriam Miguel-Ferrero2, Bonifacio Delgado4

  • 1Department of Pediatric Surgery, Prisma Health Children's Hospital, Columbia, SC, US.

American Journal of Clinical Pathology
|July 21, 2023
PubMed
Summary
This summary is machine-generated.

Mucosal appendicitis, an early stage of acute appendicitis, shows distinct inflammatory markers. Higher leukocyte and neutrophil counts, including neutrophil-to-lymphocyte ratios, differentiate it from negative appendectomies, aiding diagnosis.

Keywords:
acute appendicitisappendectomychildrenmucosal appendicitisneutrophil to lymphocyte ratio

More Related Videos

Management of the Uncinate Process in No-Touch Laparoscopic Pancreaticoduodenectomy
09:32

Management of the Uncinate Process in No-Touch Laparoscopic Pancreaticoduodenectomy

Published on: May 5, 2023

905
Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

8.7K

Related Experiment Videos

Last Updated: Jul 22, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
00:08

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.1K
Management of the Uncinate Process in No-Touch Laparoscopic Pancreaticoduodenectomy
09:32

Management of the Uncinate Process in No-Touch Laparoscopic Pancreaticoduodenectomy

Published on: May 5, 2023

905
Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

8.7K

Area of Science:

  • Pediatric Surgery
  • Gastrointestinal Pathology
  • Diagnostic Imaging

Background:

  • Mucosal appendicitis (MA) is a controversial entity characterized by limited neutrophilic infiltration of the appendiceal mucosa.
  • Distinguishing MA from negative appendicitis (NA) is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To investigate whether mucosal appendicitis represents an early stage of acute appendicitis (AA).
  • To determine if MA can be differentiated from negative appendectomies based on clinical and laboratory findings.

Main Methods:

  • Retrospective analysis of 1269 children undergoing appendectomy for suspected appendicitis (2017-2020).
  • Histological classification into MA (30 cases) and NA (25 cases) groups.
  • Comparison of demographic, clinical, ultrasound, and laboratory parameters between groups.

Main Results:

  • No significant differences in demographic, clinical, or ultrasound features between MA and NA groups.
  • MA group showed significantly higher leukocyte and neutrophil counts and neutrophil-to-lymphocyte ratios (NLRs) (P < .001).
  • NLR demonstrated the highest area under the curve (0.736) for MA diagnosis, with a cutoff of 3.20 offering 62.5% sensitivity and 78.9% specificity.

Conclusions:

  • Mucosal appendicitis exhibits distinct laboratory and histologic inflammatory features, supporting its classification as a pathologic entity within the acute appendicitis spectrum.
  • Preoperative leukocyte and neutrophil counts, along with NLRs, can aid in reducing negative appendectomies.