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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Elevated C-reactive protein/albumin ratio in patients with methamphetamine use disorder
Ali Baran Tanrıkulu1, Hilal Kaya1, Zekiye Çatak2
1Psychiatry, Elazığ Mental Health and Diseases Hospital, Turkey Elazığ, Turkey.
International Journal of Psychiatry in Clinical Practice
|July 21, 2023
Summary
The C-reactive protein/albumin ratio (CAR) may serve as a valuable inflammatory biomarker for methamphetamine use disorder. Higher CAR levels were observed in patients, indicating its potential for monitoring treatment response.
Area of Science:
- Clinical Medicine
- Toxicology
- Biomarkers
Background:
- Methamphetamine use disorder (MUD) presents significant individual, familial, and societal challenges.
- Identifying reliable inflammatory biomarkers is crucial for assessing and monitoring MUD patients' inflammatory status.
- Existing research lacks comprehensive evaluation of specific inflammatory ratios in MUD.
Purpose of the Study:
- To investigate the potential of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), C-reactive protein/albumin ratio (CAR), and neutrophil/albumin ratio (NAR) as inflammatory biomarkers in MUD.
- To compare these ratios between individuals with MUD and healthy controls.
- To determine the predictive value of these ratios for MUD.
Main Methods:
- A case-control study involving 139 hospitalized MUD patients and 139 matched healthy controls.
- Data collection included demographic information and laboratory-assessed inflammatory markers.
- Statistical analyses comprised independent sample t-tests, Pearson's correlation, and binomial logistic regression.
Main Results:
- CAR and NAR levels were significantly elevated in the MUD group compared to controls (p=0.016 and p=0.048, respectively).
- Logistic regression analysis identified CAR as a significant predictor of MUD group membership.
- NLR, PLR, and MLR did not show significant differences between groups.
Conclusions:
- CAR emerges as a potential and practical inflammatory biomarker for MUD.
- CAR can aid in monitoring the inflammatory status and treatment efficacy in MUD patients.
- Further research is warranted to validate CAR's utility in diverse MUD populations.
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