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Updated: Jul 22, 2025
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Energy metabolism: a new target for gastric cancer treatment
Jiangrong Liu1, Xue Bai1, Meilan Zhang1
1Cancer Research Institute of Hengyang Medical School, Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, University of South China, 28 Changsheng Road, Hengyang, 421001, Hunan, People's Republic of China.
Abstract:
Gastric cancer is the fifth most common malignancy worldwide having the fourth highest mortality rate. Energy metabolism is key and closely linked to tumour development. Most important in the reprogramming of cancer metabolism is the Warburg effect, which suggests that tumour cells will utilise glycolysis even with normal oxygen levels. Various molecules exert their effects by acting on enzymes in the glycolytic pathway, integral to glycolysis. Second, mitochondrial abnormalities in the reprogramming of energy metabolism, with consequences for glutamine metabolism, the tricarboxylic acid cycle and oxidative phosphorylation, abnormal fatty acid oxidation and plasma lipoprotein metabolism are important components of tumour metabolism. Third, inflammation-induced oxidative stress is a danger signal for cancer. Fourth, patterns of signalling pathways involve all aspects of metabolic transduction, and many clinical drugs exert their anticancer effects through energy metabolic signalling. This review summarises research on energy metabolism genes, enzymes and proteins and transduction pathways associated with gastric cancer, and discusses the mechanisms affecting their effects on postoperative treatment resistance and prognoses of gastric cancer. We believe that an in-depth understanding of energy metabolism reprogramming will aid the diagnosis and subsequent treatment of gastric cancer.
Insights
Gastric cancer cell metabolism reprogramming, including the Warburg effect and mitochondrial changes, drives tumor development. Understanding these energy metabolism shifts is crucial for improving gastric cancer treatment and patient outcomes.
Area of Science:
- Oncology
- Metabolic Research
- Cancer Biology
Background:
- Gastric cancer is a leading cause of cancer mortality globally.
- Tumor development is intrinsically linked to alterations in cellular energy metabolism.
- The Warburg effect, characterized by glycolysis even in aerobic conditions, is a hallmark of cancer metabolism.
Purpose of the Study:
- To review current research on energy metabolism in gastric cancer.
- To explore the role of genes, enzymes, proteins, and signaling pathways in gastric cancer metabolism.
- To discuss how metabolic reprogramming influences treatment resistance and prognosis.
Main Methods:
- Literature review of studies on gastric cancer and energy metabolism.
- Analysis of key metabolic pathways including glycolysis, mitochondrial function, and fatty acid metabolism.
- Examination of the impact of inflammation and oxidative stress on cancer metabolism.
- Investigation of signaling pathways involved in metabolic transduction.
Main Results:
- Reprogramming of energy metabolism, including the Warburg effect and mitochondrial abnormalities, is central to gastric cancer.
- Altered glutamine metabolism, tricarboxylic acid cycle, oxidative phosphorylation, and fatty acid oxidation are significant.
- Inflammation-induced oxidative stress acts as a cancer danger signal.
- Metabolic signaling pathways are implicated in the efficacy of anticancer drugs.
Conclusions:
- Understanding the complex reprogramming of energy metabolism is vital for advancing gastric cancer diagnosis.
- Targeting metabolic pathways offers potential for novel therapeutic strategies.
- Insights into metabolic alterations can improve predictions of treatment response and patient prognosis.
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