Targeting YTHDF2/MDSCs to improve radiotherapy
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Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
Published on: May 17, 2019
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Xiaolan Deng1, Ying Qing1, Jianjun Chen2
1Department of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Cell Chemical Biology
|July 21, 2023
Abstract:
Immunosuppression contributes to tumor-radiotherapy failure, but the mechanism remains elusive. Wang et al.1 reported that ionizing radiation (IR) induces YTHDF2 expression in myeloid-derived suppressor cells (MDSCs) via an IR-YTHDF2-NF-κB circuit, which contributes to MDSC expansion/migration and treatment failure. Genetic depletion or pharmacological inhibition of YTHDF2 overcomes immunosuppression and improves radiotherapy.

