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An exploratory study on the association between serotonin and sleep breathing disorders
Mieszko Wieckiewicz1, Helena Martynowicz2, Gilles Lavigne3
1Department of Experimental Dentistry, Wroclaw Medical University, Wroclaw, Poland. m.wieckiewicz@onet.pl.
Scientific Reports
|July 21, 2023
Summary
Lower blood serotonin and higher tryptophan hydroxylase 1 (TPH1) levels may be linked to sleep-disordered breathing. This study explored serotonin
Area of Science:
- Biochemistry
- Sleep Medicine
- Neuroscience
Background:
- Serotonin plays a role in regulating sleep and breathing.
- The relationship between serotonin metabolism and sleep-disordered breathing (SDB) requires further investigation.
Purpose of the Study:
- To investigate the association between blood serotonin levels, serotonin synthesis enzymes (TPH1 and AADC), and sleep breathing parameters.
Main Methods:
- Observational study including 105 patients undergoing polysomnography.
- Measurement of serum serotonin, TPH1, and AADC levels.
- Correlation analysis between biochemical markers and SDB indices.
Main Results:
- Negative correlation observed between blood serotonin and oxygen desaturation index (ODI), central apnea, and obstructive apnea (OA) scores.
- TPH1 levels showed negative correlation with average/minimal oxygen saturation and positive correlation with apnea-hypopnea index (AHI), OA, and hypopnea index (HI).
Conclusions:
- Findings suggest a potential link between lower blood serotonin, higher TPH1 levels, and a tendency towards sleep-disordered breathing.
- Further research is warranted to elucidate the role of serotonin in SDB pathophysiology.
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