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Nanotechnology-based ocular drug delivery systems: recent advances and future prospects
Shiding Li1,2, Liangbo Chen1,2, Yao Fu3,4
1Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of Nanobiotechnology
|July 21, 2023
Summary
Ocular drug delivery faces challenges from eye barriers. Nanotechnology offers promising solutions for improved ophthalmic drug delivery systems, addressing these constraints.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Nanotechnology
Background:
- Ocular drug delivery is hindered by anatomical and physiological barriers within the eye.
- These barriers limit the absorption and efficacy of therapeutic agents for ocular diseases.
- Effective drug therapy is crucial for managing conditions like glaucoma.
Purpose of the Study:
- To review ocular anatomy, disease constraints, and current therapies.
- To highlight advances in ocular drug delivery, focusing on nanotechnology.
- To summarize nanocarrier characterizations, market status, and future research directions.
Main Methods:
- Review of ocular anatomy and physiological barriers.
- Analysis of common ocular diseases and existing treatments.
- Exploration of nanotechnology-based ocular drug delivery systems.
- Summarization of research, clinical trials, and patents.
Main Results:
- Nanotechnology-based systems show significant potential for overcoming ocular barriers.
- Characterization data for various nanocarriers are compiled.
- Current market and clinical trial status of nanotech ophthalmic drugs are presented.
Conclusions:
- Novel ocular drug delivery systems face challenges but offer future therapeutic potential.
- Nanotechnology is key to developing advanced ophthalmic formulations.
- Further research is needed to optimize nanocarrier design and application.
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