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Novel target and treatment agents for natural killer/T-cell lymphoma

Xiao-Peng Tian1,2, Yi Cao1,2, Jun Cai1,2

  • 1Department of Medical Oncology, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, No. 651, Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

Journal of Hematology & Oncology
|July 21, 2023
PubMed

Insights

Novel treatments are improving outcomes for natural killer/T-cell lymphoma (NKTCL). This review covers emerging therapies like targeted antibodies and immunotherapies, offering hope for relapsed or refractory NKTCL patients.

Area of Science:

  • Oncology
  • Immunology
  • Hematology

Background:

  • High-throughput screening has expanded knowledge of natural killer/T-cell lymphoma (NKTCL) molecular basis.
  • Asparaginase-containing regimens have significantly improved survival in NKTCL patients.

Purpose of the Study:

  • To review novel treatment strategies for NKTCL.
  • To discuss the future potential of these treatments in a wider clinical setting.

Main Methods:

  • Review of current and emerging NKTCL treatments.
  • Analysis of clinical study results for novel therapies.

Main Results:

  • Asparaginase-based regimens show substantial survival benefits.
  • Emerging therapies include targeted antibodies, immune checkpoint inhibitors, and CAR T-cells.
  • Initial studies often focus on relapsed/refractory NKTCL due to limited options.

Conclusions:

  • Novel therapies demonstrate promise for NKTCL treatment.
  • Further research and wider application of these treatments are anticipated.
Keywords:
ImmunotherapyNatural killer/T-cell lymphomaNovel agentsTargeted therapy

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