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[Physiologic, pathologic and manipulated body growth].

A Prader

    Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    Human growth is complex, influenced by many factors and showing distinct patterns from infancy to adulthood. This study analyzes growth standards, predicting adult height and exploring variations like catch-up growth.

    Area of Science:

    • Pediatric endocrinology and human growth and development.

    Context:

    • Leverages the comprehensive Zurich growth studies, a long-term observational dataset.
    • Examines multifactorial influences on growth trajectories from infancy through adulthood.

    Purpose:

    • To delineate normal growth patterns, including distance and velocity curves.
    • To analyze sex-specific and sex-independent growth phenomena.
    • To establish standards for intra- and extra-uterine growth and predict adult height.

    Summary:

    • Discusses secular trends in growth, sex dependency in maturation and pubertal spurts, and independence of adult size from pubertal timing.
    • Details growth standards, perinatal assessments, and correlations between current height, parental height, and estimated adult height.
    • Explores hormonal interventions, extreme normal variations, catch-up growth, and catch-down growth phenomena.

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    Impact:

    • Provides a robust framework for understanding and monitoring normal human growth.
    • Offers tools for predicting adult height and identifying deviations from typical development.
    • Informs clinical practice regarding growth assessment, hormonal interventions, and management of growth disorders.