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Association of Thrombotic Markers With Severity of Pediatric-Onset Systemic Lupus Erythematosus

Sheren Esam Maher1, Ahmed Ragab Abdul-Badia1, Mostafa Ahmed Abu El-Ela2

  • 1Department of Pediatrics, Faculty of Medicine, Minia University, El-Minya, Egypt.

Indian Pediatrics
|July 22, 2023
PubMed

Insights

Thrombomodulin and D-dimer levels are elevated in children with pediatric systemic lupus erythematosus (p-SLE). Higher levels of these thrombotic markers correlate with increased disease activity, aiding in distinguishing severe cases.

Area of Science:

  • Pediatric Rheumatology
  • Hematology
  • Immunology

Background:

  • Pediatric-onset systemic lupus erythematosus (p-SLE) is a chronic autoimmune disease with variable clinical manifestations.
  • Assessing disease activity and identifying predictive markers are crucial for effective management of p-SLE.
  • Thrombotic events can be a serious complication in patients with SLE.

Purpose of the Study:

  • To investigate the relationship between thrombotic markers, specifically thrombomodulin and D-dimer, and disease severity in pediatric-onset systemic lupus erythematosus (p-SLE).
  • To determine if these markers can differentiate between low and moderate-to-high disease activity levels in children with p-SLE.

Main Methods:

  • A cohort of 40 children diagnosed with p-SLE was divided into low activity (laSLE) and moderate-high activity (mhaSLE) groups based on the Systemic Lupus Erythematous Disease Activity Index (SLEDAI).
  • Forty healthy children served as a control group.
  • Serum levels of thrombomodulin and D-dimer were quantified in all participants.

Main Results:

  • Children with p-SLE, across both activity groups, exhibited significantly higher mean thrombomodulin and D-dimer levels compared to healthy controls.
  • The moderate-high activity SLE (mhaSLE) group demonstrated significantly elevated thrombomodulin and D-dimer levels compared to the low activity SLE (laSLE) group.
  • Both thrombomodulin and D-dimer showed significant positive correlations with SLEDAI scores, indicating a link to disease severity.

Conclusions:

  • Thrombomodulin and D-dimer serve as valuable biomarkers for assessing disease activity in p-SLE.
  • These markers effectively distinguish children with severe p-SLE activity from those with milder disease, aiding in clinical stratification.
Abstract

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